Otto-von-Guericke-Universität Magdeburg



Adaptive Designs for Dose Escalation Studies

by Roth, K.


Preprint series: 09-08, Preprints

62K05 Optimal designs
62L05 Sequential design
62P10 Applications to biology


Abstract: In Phase I dose escalation studies the 3+3 design is a commonly used method. We suggest a modification of this method to include a parametric model and the concepts of optimal design theory, with the aim of improving this method. The performance of the original and the new approach are investigated by simulations.

Keywords: optimal design, adaptive design, dose escalation studies

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Letzte Änderung: 10.02.2016 - Ansprechpartner: Pierre Krenzlin